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In Vivo Formation of Protein Corona on Gold Nanoparticles. The effect of Size and Shape

Abstract

protein corona. Although several determinant factors involved in protein corona formation have been identified from in vitro studies, specific relationships between the nanomaterial synthetic identity and its ensuing biological identity under realistic in vivo conditions remains elusive. We present here a detailed study of in vivo protein corona fromation after blood circulation of anisotropic gold nanoparticles (nanorods and nanostars). Plasmonic gold nanoparticles of different shapes and sizes were coated with polyethyleneglycol, intravenously administered in CD-1 mice and subsequently recovered. The results from gel electrophoresis and mass spectrometry analysis revealed the fromation of complex protein coronas, as early as 10 minutes post-injection. The toal amount of protein adsorbed onto the particle surface, as well as the protein corona composition were found to be affected by both particle size and shape.

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Publication details

The article was received on 08 Nov 2017, accepted on 04 Dec 2017 and first published on 07 Dec 2017


Article type: Paper
DOI: 10.1039/C7NR08322J
Citation: Nanoscale, 2017, Accepted Manuscript
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    In Vivo Formation of Protein Corona on Gold Nanoparticles. The effect of Size and Shape

    R. García-Alvarez, M. Hadjidemetriou, A. Sánchez-Iglesias, L. M. Liz-Marzan and K. Kostarelos, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR08322J

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