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Issue 48, 2017
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Non-invasive detection of gastric cancer relevant D-amino acids with luminescent DNA/silver nanoclusters

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Abstract

Chirality plays essential roles in life systems such that L-amino acids (LAAs) are predominantly found as the building units of protein for organisms. The presence of the D-enantiomer (DAA) has been found to be specifically relevant to gastric cancer. We herein construct a luminescent DNA/silver nanocluster based biosensing system to achieve rapid and specific detection of DAAs. As a proof of application, we detected DAAs in saliva samples from patients with gastric cancer, and the test results exhibited excellent specificity. Our detection system has the following major advantages: (i) the detection is rapid, being completed in less than 1 hour; (ii) the limit of detection falls in the effective range of DAA concentrations of gastric cancer at an early stage, indicating that our method is potentially suitable for early diagnosis of gastric cancer; (iii) the non-invasive sampling manner provides an adaptable system for point-of-care testing (POCT); and (iv) the system does not require any massive instruments or expensive reagents, which enables POCT as well.

Graphical abstract: Non-invasive detection of gastric cancer relevant d-amino acids with luminescent DNA/silver nanoclusters

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Publication details

The article was received on 02 Oct 2017, accepted on 11 Nov 2017 and first published on 16 Nov 2017


Article type: Paper
DOI: 10.1039/C7NR07337B
Citation: Nanoscale, 2017,9, 19367-19373
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    Non-invasive detection of gastric cancer relevant D-amino acids with luminescent DNA/silver nanoclusters

    Z. Zhang, Y. Liu, P. Liu, L. Yang, X. Jiang, D. Luo and D. Yang, Nanoscale, 2017, 9, 19367
    DOI: 10.1039/C7NR07337B

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