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Multifunctional Cu-Ag2S nanoparticles with high photothermal conversion efficiency for photoacoustic imaging guided photothermal therapy in vivo

Abstract

Photothermal therapy (PTT) has attracted increasing interest and became more widely used for cancer therapy, owing to its noninvasiveness and low systemic adverse effects. However, there is an urgent need to develop biocompatible and multifunctional PTT agents with high photothermal conversion efficiency. Herein, the biocompatible Cu-Ag2S/PVP NPs with significantly strong near-infrared absorption and high photothermal conversion efficiency were successfully synthesized for high performance photoacoustic (PA) imaging-guided photothermal therapy in vivo. The novel Cu-Ag2S/PVP NPs features high photothermal conversion efficiency (58.2%) under 808 nm light irradiation, noticeably higher than most of the reported PTT agents. Owing to good dispersibility, Cu-Ag2S/PVP NPs passively accumulate within tumor through the enhanced permeability and retention effect, which can be confirmed by PA imaging, photothermal performance, and biodistribution in vivo. Furthermore, Cu-Ag2S/PVP NPs can be thoroughly cleared through feces and urine within 7 days, showing high biosafety for further potential clinical translation.

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Publication details

The article was received on 29 Sep 2017, accepted on 29 Nov 2017 and first published on 05 Dec 2017


Article type: Paper
DOI: 10.1039/C7NR07263E
Citation: Nanoscale, 2017, Accepted Manuscript
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    Multifunctional Cu-Ag2S nanoparticles with high photothermal conversion efficiency for photoacoustic imaging guided photothermal therapy in vivo

    L. Dong, G. Ji, Y. Liu, X. Xu, P. Lei, K. Du, S. Song, J. Feng and H. Zhang, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR07263E

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