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Triphenylamine Flanked Furan-diketopyrrolopyrrole for Multi-imaging Guided Photothermal/Photodynamic Cancer Therapy

Abstract

The combination of photodynamic therapy (PDT) and photothermal therapy (PTT) is highly desired to improve cancer phototherapeutic effect. However, most reported multicomponent therapeutic agents need complex preparation processes and must be excited by multiple light sources. Herein, triphenylamine flanked furan-diketopyrrolopyrrole (FDPP-TPA) with donor-acceptor-donor (D-A-D) structure has been synthesized and used as sole-component for fluorescence, photoacoustic and photothermal imaging guided photodynamic and photothermal synergistic therapy. More important, FDPP-TPA nanoparticles (NPs) obtained by re-precipitation exhibit high molar extinction coefficient (ε = 2.13 (± 0.2) × 104 M-1 cm-1), excellent photothermal conversion efficiency (η = 47%) and favorable singlet oxygen quantum yield (ФΔ(X) = 40%). In vitro, half-maximal inhibitory concentration (IC50) is 13 μg/mL determined by cytotoxicity assay suggesting its high phototoxicity. And apoptosis rate is 67.3% according to flow cytometry analysis. In vivo, tumor can be completely ablated without recurrence, which suggests FDPP-TPA NPs can generate considerable poisonous singlet oxygen and hyperthermia for tumor treatment.

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Publication details

The article was received on 27 Sep 2017, accepted on 07 Nov 2017 and first published on 08 Nov 2017


Article type: Paper
DOI: 10.1039/C7NR07204J
Citation: Nanoscale, 2017, Accepted Manuscript
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    Triphenylamine Flanked Furan-diketopyrrolopyrrole for Multi-imaging Guided Photothermal/Photodynamic Cancer Therapy

    X. Dong, P. Liang, Y. Wang, P. wang, J. Zou, H. Xu, Y. Zhang and W. Si, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR07204J

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