Jump to main content
Jump to site search


A specific Hela cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

Abstract

In this study, water-soluble PEG-modified Sr2YbF7: Tm3+ was prepared conveniently by one-pot solvothermal method, thereinto, the molar ratio of Sr2+ to Yb3+ was controlled between 3:2 and 1:1. The optimum red-light emission at 677-699 nm was modulated via 0.7% Tm3+ doped under irradiation at 980 nm. Interestingly, biological experiment results showed that the PEG-modified Sr2YbF7:Tm3+ with low toxicity, excellent cell membrane permeability and high photostability can not only distinguish HeLa cells from Mouse Embryonic Fibroblast but also target subcellular organelle lysosome in HeLa cells, which anticipated that the as-prepared material would be a potential tool for cancer diagnosis.

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Sep 2017, accepted on 05 Nov 2017 and first published on 06 Nov 2017


Article type: Paper
DOI: 10.1039/C7NR07093D
Citation: Nanoscale, 2017, Accepted Manuscript
  •   Request permissions

    A specific Hela cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

    L. Xiang, H. Zhang, H. Li, L. Kong, H. Zhou, J. Wu, Y. Tian, J. Zhang and Y. Mao, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR07093D

Search articles by author

Spotlight

Advertisements