Jump to main content
Jump to site search


Mucopenetrating micelles with a PEG corona

Author affiliations

Abstract

Crossing the intestinal mucus layer is a long-standing challenge for orally delivered nanoparticles carrying therapeutic cargo. We report the assembly of mucopenetrating cargo-loaded micelles using block copolymers consisting of either linear poly(ethylene glycol) (PEG) or bottle-brush poly(oligo(ethylene glycol)methacrylate) (PEGb) as the hydrophilic block and poly(caprolactone) (PCL) or poly(cholesteryl methacrylate) (PCMA) as the hydrophobic extension. The micelles were shown to preserve their stability and retain ∼50% of their cargo in simulated gastric fluid. The ability of micelles to diffuse through reconstituted porcine mucus was assessed in a microfluidic set-up. Finally, the delivery of Nile Red as a hydrophobic model cargo across a mucus layer produced by epithelial cells was demonstrated. These engineered mucopenetrating micelles have potential to be developed into efficient absorption enhancers, contributing a nanotechnology solution to oral drug delivery.

Graphical abstract: Mucopenetrating micelles with a PEG corona

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Sep 2017, accepted on 30 Oct 2017 and first published on 31 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR06821B
Citation: Nanoscale, 2017, Advance Article
  •   Request permissions

    Mucopenetrating micelles with a PEG corona

    E. M. Taipaleenmäki, S. A. Mouritzen, P. S. Schattling, Y. Zhang and B. Städler, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR06821B

Search articles by author

Spotlight

Advertisements