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Mucopenetrating Micelles with a PEG Corona

Abstract

Crossing the intestinal mucus layer is a long-standing challenge for orally delivered nanoparticles carrying therapeutic cargo. We report the assembly of mucopenetrating cargo-loaded micelles using block copolymers consisting of either linear poly(ethylene glycol) (PEG) or bottle-brush poly(oligo(ethylene glycol) methacrylate) (PEGb) as the hydrophilic block and poly(caprolactone) (PCL) or poly(cholesteryl methacrylate) (PCMA) as the hydrophobic extension. The micelles were shown to preserve their stability and retain ~50% of their cargo in simulated gastric fluid. The micelles’ ability to diffuse through reconstituted porcine mucus was assessed in a microfluidic set-up. Finally, the delivery of Nile red as a hydrophobic model cargo across a mucus layer produced by epithelial cells was demonstrated. These engineered mucopenetrating micelles have the potential to be developed into efficient absorption enhancers, contributing a nanotechnolgy solution to oral drug delivery.

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Publication details

The article was received on 13 Sep 2017, accepted on 30 Oct 2017 and first published on 31 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR06821B
Citation: Nanoscale, 2017, Accepted Manuscript
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    Mucopenetrating Micelles with a PEG Corona

    E. Taipaleenmaki, S. A. Mouritzen, P. Schattling, Y. Zhang and B. Städler, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR06821B

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