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Osteoinductive Superparamagnetic Fe nanocrystal/Calcium Phosphate Heterostructured Microspheres

Abstract

Functional magnetic and biocompatible particles are of great interest because of their potential use as various bioapplications such as hyperthermia for cancer treatment, magnetic resonance imaging (MRI) contrast agent and drug delivery. Herein, we introduce a facile method for synthesizing magnetic Fe nanocrystal/Fe-substituted calcium phosphate (Fe/FeCaP) heterostructure microspheres using a two-step procedure: 1) one-pot hydrothermal synthesis to prepare uniform-sized FeCaP microspheres and 2) post-reduction annealing at 600 °C for Fe extraction from FeCaP. This approach results in the fabrication of Fe/FeCaP heterostructure microspheres that exhibit superparamagnetism with saturation magnetization of 10.77 emu/g. The Fe/FeCaP particles annealed at 600 °C show much a higher magnetic moment compared with the non-annealed FeCaP particles. Moreover, T2-weighted MRI phantom images reveal that the Fe/FeCaP heterostructured microspheres possess higher relaxivity than paramagnetic FeCaP, demonstrating their potential as superior and biocompatible MRI contrast agents. Moreover, the enhancement in osteoconductivity for Fe/FeCaP microsphere without any evidence of cytotoxicity was verified. Our results demonstrate a great potential of multi-functional Fe/FeCaP spheres for use as biocompatible bone regeneration agents as well as MRI contrast agents.

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Publication details

The article was received on 11 Sep 2017, accepted on 11 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7NR06777A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Osteoinductive Superparamagnetic Fe nanocrystal/Calcium Phosphate Heterostructured Microspheres

    S. Y. Park, S. K. MP, J. Park, S. W. Kim, H. Shin, S. P. Park and H. S. Jung, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR06777A

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