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Injectable Functionalized Self-assembling Nanopeptide Hydrogel on Angiogenesis and Neurogenesis for Central Nervous System Regeneration

Abstract

Brain injury is a devastating medical condition and represents a major health problem. For such disease, tissue and organ reconstruction has been regarded as a promising therapeutic strategy. Here, we propose a regenerative methodology focusing on the provision of functionalized nanopeptide scaffold to facilitate angiogenesis and neurogenesis at the brain injury site. The peptide, RADA16-SVVYGLR, undergoes self-assembling process to construct an interconnected network with intertwining nanofibers and can be controlled to display various physicochemical properties by the adjustment of microenvironmental factors such as pH value and ions concentration. Such scaffold is capable of supporting endothelial cells to form tube-like structure and neural stem cells to survive and proliferate. In in vivo zebrafish brain injury model, sprouting angiogenesis and developmental neurogenesis are achieved, and functional recovery of severed optic tectum is effectively enhanced in RADA16-SVVYGLR hydrogel-implanted group. Meanwhile, the nanopeptide hydrogel is non-toxic to zebrafish embryo during embryonic developmental stage. The angiogenic self-assembling peptide hydrogel has programmable physical properties, good biocompatibility, and regenerative ability for functional recovery in the injured brain. We suggest that functionalized self-assembling peptide encapsulated with neural stem cells or used alone could be an attractive and effective therapeutic modality for the applications in brain injury and diseases (viz., trauma, stroke, tumor, degenerative neurological disorder, etc).

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Publication details

The article was received on 01 Sep 2017, accepted on 04 Oct 2017 and first published on 06 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR06528K
Citation: Nanoscale, 2017, Accepted Manuscript
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    Injectable Functionalized Self-assembling Nanopeptide Hydrogel on Angiogenesis and Neurogenesis for Central Nervous System Regeneration

    T. Wang, K. Chang, L. Chen, S. Liao, C. Yeh and Y. Chuang, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR06528K

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