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Nanocarriers with multi-locked DNA valves targeting to intracellular tumor-related mRNAs for controlled drug release

Abstract

The fabrication of well-behaved drug delivery systems that can strictly transport drugs to treat the cancer cells rather than normal cells is still a tremendous challenge. A novel drug delivery system with two types of tumor-related mRNAs as “keys” to open the multiple valves of nanocarrier to control drug release has now been developed. Hollow mesoporous silica nanoparticles were employed as nanocarrier and dual DNAs targeting to two intracellular mRNAs were employed as “multi-locks” to lock up the nanocarrier. When the nanocarrier entered cancer cells, the overexpressed endogenous mRNA keys would hybridize with the DNA multi-locks to open the valves and release drugs. Each single mRNA could not trigger to open the locks to release cargoes. Therefore, the nanocarrier can be applied for specific chemotherapy against cancer cells with little side effects to the normal cells. The current strategy could provide important avenues to advance practical applications of drug delivery systems for cancer therapy.

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Supplementary files

Publication details

The article was received on 31 Aug 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR06479A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Nanocarriers with multi-locked DNA valves targeting to intracellular tumor-related mRNAs for controlled drug release

    Y. Li, Y. Chen, W. Pan, Z. Yu, L. Yang, H. Wang, N. Li and B. Tang, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR06479A

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