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Cellular traction forces: a useful parameter in cancer research

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Abstract

The search for new cancer biomarkers is essential for fundamental research, diagnostics, as well as for patient treatment and monitoring. Whereas most cancer biomarkers are biomolecules, an increasing number of studies show that mechanical cues are promising biomarker candidates. Although cell deformability has been shown to be a possible cancer biomarker, cellular forces as cancer biomarkers have been left largely unexplored. Here, we measure traction forces of cancer and normal-like cells at high spatial resolution using a robust method based on dense vertical arrays of nanowires. A force map is created using automated image analysis based on the localization of the fluorescent tips of the nanowires. We show that the force distribution and magnitude differ between MCF7 breast cancer cells and MCF10A normal-like breast epithelial cells, and that monitoring traction forces can be used to investigate the effects of anticancer drugs.

Graphical abstract: Cellular traction forces: a useful parameter in cancer research

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Publication details

The article was received on 23 Aug 2017, accepted on 21 Nov 2017 and first published on 24 Nov 2017


Article type: Communication
DOI: 10.1039/C7NR06284B
Citation: Nanoscale, 2017, Advance Article
  • Open access: Creative Commons BY license
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    Cellular traction forces: a useful parameter in cancer research

    Z. Li, H. Persson, K. Adolfsson, L. Abariute, M. T. Borgström, D. Hessman, K. Åström, S. Oredsson and C. N. Prinz, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR06284B

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