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Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles

Abstract

The possibility of combining more than one stimulus-responsive property into a single material holds interesting potential for the creation of adaptive devices to be used in diverse fields such as drug delivery, nanomedicine and tissue engineering. This paper describes a novel material based on thermo-responsive PNIPAm nanopillars with amplified surface properties through the incorporation of Fe3O4 nanoparticles. The incorporation of magnetic nanoparticles into the nanopillars, prepared via surface-initiated atom-transfer radical polymerization in anodized aluminum oxide templates, sharply increased their stiffness and hydrophobicity when increasing te temperature above the volume phase transition temperature. Furthermore, their magnetic response resulted proportional to the amount of incorporated nanoparticles. The possibility of sharply increasing the stiffness with a temperature variation close to the human body temperature paves the way to the application of these substrates as "smart" scaffolds for cell culture. Additionally, the presence of superparamagnetic nanoparticles in the nanopillars offers the possibility of using these nanostructured systems for magnetic hyperthermia.

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Publication details

The article was received on 20 Aug 2017, accepted on 06 Dec 2017 and first published on 06 Dec 2017


Article type: Paper
DOI: 10.1039/C7NR06209E
Citation: Nanoscale, 2017, Accepted Manuscript
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    Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles

    J. M. Giussi, C. von Bilderling, E. Alarcón, L. Pietrasanta, R. Hernandez, R. Perez del Real, M. vazquez, C. Mijangos, L. Cortez and O. Azzaroni, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR06209E

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