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Nanofabrication of mechano-bactericidal surfaces

Abstract

The adaptation of bacteria to survive in the presence of antibiotics, and their ability to form biofilms on conventional antibacterial surfaces has seen the increase of persistent infections caused by resistant strains of bacteria. Common, infection-causing bacteria are now characterised by not only one antibiotic resistance, but multiple drug resistances. Antibiotic resistance presents a worldwide health epidemic which can only be mitigated through the search for a new generation of biomaterials, as an alternative to standard methods for preventing bacterial adhesion and biofilm formation. This search has led to the use of biomimetics to reinvent, through nanofabrication methods, surfaces whereby the nanostructured topography is directly responsible for bacterial inactivation through physico-mechanical means. Plant leaves, insect wings and animal skin have all been used to inspire the fabrication of synthetic high-aspect ratio nanopillared surfaces, which can resist bacterial colonisation. This review outlines the nanofabrication techniques and the material involved in the construction of various bactericidal surfaces.

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Publication details

The article was received on 09 Aug 2017, accepted on 12 Oct 2017 and first published on 13 Oct 2017


Article type: Review Article
DOI: 10.1039/C7NR05881K
Citation: Nanoscale, 2017, Accepted Manuscript
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    Nanofabrication of mechano-bactericidal surfaces

    D. P. Linklater, S. Juodkazis and E. P. Ivanova, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05881K

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