Jump to main content
Jump to site search


CARBOSILANE DENDRONS WITH FATTY ACIDS AT THE CORE AS A NEW POTENTIAL MICROBICIDE AGAINST HSV-2/HIV-1 CO-INFECTION.

Abstract

Herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) represent the two most frequent sexually transmitted infections (STI) worldwide. Epidemiological studies suggest that HSV-2 increases the risk of HIV-1 acquisition approximately 3-fold mainly due to the clinical and immunological manifestations. In the absence of vaccines against both STI, the development of new preventive strategies has become essential for further studies. We performed screening of six novel polyanionic carbosilane dendrons to elucidate their potential activity against HSV-2/HIV-1 co-infection and their mechanism of action. These new nanoparticles are carbosilane branched dendrons from first to third generation, with palmitic or hexanoic fatty acids as core and capped with sulfonate groups, named as G1d-STE2Hx, G2d-STE4Hx, G3d-STE8Hx, G1d-STE2Pm, G2d-STE4Pm and G3d-STE8Pm. G3d-STE8Hx and G3d-STE8Pm carbosilane branched dendrons showed high viability. These dendrons also showed a great broad-spectrum antiviral activity, as well as a suitable efficacy against HIV-1 even if the mucosal disruption occurs as consequence of HSV-2 infection. Our results exert high inhibition against HSV-2 and HIV-1 by blocking the entry of both viruses with the median effective concentration EC50 values in the nanomolar range. Additionally, G3d-STE8Hx and G3d-STE8Pm retained their anti-HSV-2/HIV-1 activity at different pH. G3d-STE8Hx and G3d-STE8Pm dendrons may be potential candidates as dual-acting microbicide against HSV-2/HIV-1 co-infection.

Back to tab navigation

Publication details

The article was received on 08 Aug 2017, accepted on 05 Oct 2017 and first published on 09 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR05859D
Citation: Nanoscale, 2017, Accepted Manuscript
  •   Request permissions

    CARBOSILANE DENDRONS WITH FATTY ACIDS AT THE CORE AS A NEW POTENTIAL MICROBICIDE AGAINST HSV-2/HIV-1 CO-INFECTION.

    C. Guerrero-Beltrán, R. Ceña-Diez, D. Sepúlveda-Crespo, J. de la Mata, R. Gómez Ramírez, M. Leal, M. Á. Muñoz-Fernández and J. L. Jimenez, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05859D

Search articles by author

Spotlight

Advertisements