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Issue 42, 2017
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A novel upconversion luminescence derived photoelectrochemical immunoassay: ultrasensitive detection to alpha-fetoprotein

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Abstract

Fabrication of near-infrared light-triggered photoelectrochemical (PEC) sensors based on the upconversion nanophosphors (UCNPs) is a novel approach, which exhibits the advantages of low background signal and non-damage to the biological substance as well as high sensitivity and improved electric detection in PEC sensors. Herein we demonstrate the preparation of novel and high-quality ZnO inverse opal photonic crystals (IOPCs)/Ag/NaYF4:Yb,Tm hybrid films by different advanced film techniques, including colloidal self-assembling, vapor phase deposition and pulsed laser deposition and its application to sensitive detection of alpha-fetoprotein (AFP). In the complex device, ZnO IOPCs and surface plasmon resonance (SPR) of silver had ability to largely enhance local excitation electromagnetic field of NaYF4:Yb,Tm, resulting in efficient near-infrared to visible/ultraviolet upconversion luminescence (UCL). The ultraviolet light emitted by NaYF4:Yb,Tm could b further reabsorbed by ZnO, generating PEC responses. Furthermore, because of the high specific surface area of ZnO IOPCs and the conductivity of Ag films, ZnO IOPCs/Ag/NaYF4:Yb,Tm hybrid films based near-infrared light-triggered PEC sensors showed ultrasensitive detection of AFP with a linear range from 0.05 ng mL−1 to 100 ng mL−1 and a low detection limit of ∼0.04 ng mL−1 (40 pg mL−1). Such an advanced device also shows promise in detection of other cancer markers in clinical and biological analysis.

Graphical abstract: A novel upconversion luminescence derived photoelectrochemical immunoassay: ultrasensitive detection to alpha-fetoprotein

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Publication details

The article was received on 29 Jul 2017, accepted on 02 Oct 2017 and first published on 04 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR05577C
Citation: Nanoscale, 2017,9, 16357-16364
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    A novel upconversion luminescence derived photoelectrochemical immunoassay: ultrasensitive detection to alpha-fetoprotein

    X. Chen, W. Xu, Y. Jiang, G. Pan, D. Zhou, J. Zhu, H. Wang, C. Chen, D. Li and H. Song, Nanoscale, 2017, 9, 16357
    DOI: 10.1039/C7NR05577C

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