Jump to main content
Jump to site search


Fe3O4-AuNPs Anchored 2D Metal-Organic Framework Nanosheets with DNA Regulated Switchable Peroxidase-Like Activity

Abstract

Two-dimensional (2D) metal-organic framework (MOF) nanosheets emerging as a new member of the 2D family have received significant research interests in recent years. Herein, we have successfully synthesized a 2D copper-based MOF nanosheets with bimetallic anchorage using a facile two-step process at room temperature and ambient pressure, marked as Cu(HBTC)-1/Fe3O4-AuNPs nanosheets. The as-synthesized 2D bimetallic MOF nanosheets displayed enhanced peroxidase-like activity with relatively high catalytic velocity and affinity with substrates compared with previously reported peroxidase mimics. Furthermore, its intrinsic peroxidase-like catalytic activity could be flexibly regulated by single-stranded DNA (ssDNA), exhibiting the enhancement of 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation or inhibition of 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) oxidation due to the adsorption of ssDNA via π-π stacking. Accordingly, on the basis of its peroxidase-like activity, our prepared 2D bimetallic immobilized MOF nanosheets achieved ultra-sensitive detection for H2O2 with a linear range of 2.86 to 71.43 nM, and comparable detection performance for glucose with a linear range of 12.86 to 257.14 μM. By means of its controllable peroxidase-like activity, a versatile colorimetric sensing platforms was developed and realized the detection for sulfadimethoxine (SDM) with a linear range of 3.57 to 357.14 μg/L and the limit of detection (LOD) of 1.70 μg/L. With the multiplexed performance for detecting various targets, our as-synthesized bimetallic MOF nanosheets holds great promise for the applications in environmental monitoring, as well as bioassay by virtue of its well biocompatibility.

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jul 2017, accepted on 03 Nov 2017 and first published on 07 Nov 2017


Article type: Paper
DOI: 10.1039/C7NR05541B
Citation: Nanoscale, 2017, Accepted Manuscript
  •   Request permissions

    Fe3O4-AuNPs Anchored 2D Metal-Organic Framework Nanosheets with DNA Regulated Switchable Peroxidase-Like Activity

    B. Tan, H. Zhao, W. Wu, X. Liu, Y. Zhang and X. Quan, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05541B

Search articles by author

Spotlight

Advertisements