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Fe3O4-AuNPs Anchored 2D Metal-Organic Framework Nanosheets with DNA Regulated Switchable Peroxidase-Like Activity


Two-dimensional (2D) metal-organic framework (MOF) nanosheets emerging as a new member of the 2D family have received significant research interests in recent years. Herein, we have successfully synthesized a 2D copper-based MOF nanosheets with bimetallic anchorage using a facile two-step process at room temperature and ambient pressure, marked as Cu(HBTC)-1/Fe3O4-AuNPs nanosheets. The as-synthesized 2D bimetallic MOF nanosheets displayed enhanced peroxidase-like activity with relatively high catalytic velocity and affinity with substrates compared with previously reported peroxidase mimics. Furthermore, its intrinsic peroxidase-like catalytic activity could be flexibly regulated by single-stranded DNA (ssDNA), exhibiting the enhancement of 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation or inhibition of 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) oxidation due to the adsorption of ssDNA via π-π stacking. Accordingly, on the basis of its peroxidase-like activity, our prepared 2D bimetallic immobilized MOF nanosheets achieved ultra-sensitive detection for H2O2 with a linear range of 2.86 to 71.43 nM, and comparable detection performance for glucose with a linear range of 12.86 to 257.14 μM. By means of its controllable peroxidase-like activity, a versatile colorimetric sensing platforms was developed and realized the detection for sulfadimethoxine (SDM) with a linear range of 3.57 to 357.14 μg/L and the limit of detection (LOD) of 1.70 μg/L. With the multiplexed performance for detecting various targets, our as-synthesized bimetallic MOF nanosheets holds great promise for the applications in environmental monitoring, as well as bioassay by virtue of its well biocompatibility.

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Publication details

The article was received on 28 Jul 2017, accepted on 03 Nov 2017 and first published on 07 Nov 2017

Article type: Paper
DOI: 10.1039/C7NR05541B
Citation: Nanoscale, 2017, Accepted Manuscript
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    Fe3O4-AuNPs Anchored 2D Metal-Organic Framework Nanosheets with DNA Regulated Switchable Peroxidase-Like Activity

    B. Tan, H. Zhao, W. Wu, X. Liu, Y. Zhang and X. Quan, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05541B

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