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Issue 38, 2017
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Biomedical nanomotors: efficient glucose-mediated insulin release

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We report herein the design of an autonomous glucose-responsive smart nanomachine for insulin (In) delivery based on ultrasound (US)-propelled nanomotors combined with an enzyme-based sensing-effector unit. Gold nanowire (AuNW) motors have been coupled with a mesoporous silica (MS) segment, which was gated with pH-responsive phenylboronic acid (PBA)-glucose oxidase (GOx) supramolecular nanovalves responsible for the insulin release. Glucose-induced protonation of the PBA groups triggers the opening of the pH-driven gate and uncapping of the insulin-loaded nanovalves. The insulin-loaded MS-Au nanomotors displayed an efficient US-driven movement that dramatically accelerates the glucose-triggered insulin release when compared to their static counterparts. Such coupling of the locomotion of nanovehicles with gated insulin-containing nanocontainers and glucose-responsive nanovalves holds great promise for the improved management of diabetes.

Graphical abstract: Biomedical nanomotors: efficient glucose-mediated insulin release

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The article was received on 27 Jul 2017, accepted on 25 Aug 2017 and first published on 28 Aug 2017

Article type: Communication
DOI: 10.1039/C7NR05535H
Citation: Nanoscale, 2017,9, 14307-14311
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    Biomedical nanomotors: efficient glucose-mediated insulin release

    P. Díez, B. Esteban-Fernández de Ávila, D. E. Ramírez-Herrera, R. Villalonga and J. Wang, Nanoscale, 2017, 9, 14307
    DOI: 10.1039/C7NR05535H

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