Jump to main content
Jump to site search


Tomographic Magnetic Particle Imaging of Cancer Targeted Nanoparticles

Abstract

Magnetic Particle Imaging (MPI) is an emerging, whole body biomedical imaging technique, with sub-millimeter spatial resolution and high sensitivity to a biocompatible contrast agent consisting of an iron oxide nanoparticle core and a biofunctionalized shell. Successful application of MPI to imaging of cancer depends on the nanoparticles (NPs) accumulating at tumors at sufficient levels relative to other sites. NPs physiochemical properties such as size, crystallographic structure and uniformity, surface coating, stability, blood circulation time and magnetization determine the efficacy of their tumor accumulation and MPI signal generation. Here, we address these criteria by presenting strategies for the synthesis and surface functionalization of efficient MPI tracers, that can target a typical murine brain cancer model and generate three dimensional images of these tumors with very high signal-to-noise ratios (SNR). Our results showed high contrast agent sensitivities that enabled us to detect 1.1ng of iron (SNR~3.9) and enhance the spatial resolution to about 600µm. The biodistribution of these NPs was also studied using near infra-red fluorescent (NIRF) and single-photon emission computed tomography (SPECT) imaging. NPs were mainly accumulated in liver and spleen and did not show any renal clearance. This first pre-clinical study of cancer targeted NPs imaged using a tomographic MPI system in an animal model, paves the way to explore new nanomedicine strategies for cancer diagnosis and therapy, using clinically safe magnetic iron oxide nanoparticles and MPI.

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jul 2017, accepted on 19 Oct 2017 and first published on 20 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR05502A
Citation: Nanoscale, 2017, Accepted Manuscript
  •   Request permissions

    Tomographic Magnetic Particle Imaging of Cancer Targeted Nanoparticles

    H. Arami, E. Teeman, A. Troska, H. Bradshaw, K. Saatchi, A. Tomitaka, S. Gambhir, U. O. Hafeli, D. Liggitt and K. Krishnan, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05502A

Search articles by author

Spotlight

Advertisements