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RGD-QD-MoS2 nanosheets for targeted fluorescent imaging and photothermal therapy of cancer

Abstract

The fast-developing nanotechnology provides unprecedented opportunities for the increasing demand of biomedicine, especially for cancer diagnostics and treatment. Here, novel multifunctional zero-dimensional-two-dimensional (0D-2D) RGD-QD-MoS2 nanosheets (NSs) with excellent fluorescence, photothermal conversion, and cancer-targeting properties were successfully prepared by functionalizing single-layer MoS2 NSs with fluorescent quantum dots (QDs) and arginine-glycine-aspartic (RGD) containing peptides. By using RGD-QD-MoS2 NSs as a multifunctional theranostic agent, targeted fluorescent imaging and photothermal therapy (PTT) of human cervical carcinoma (HeLa) cells was achieved. Moreover, HeLa tumors in mouse models can be fluorescently imaged and completely eradicated by photothermal irradiation using low power NIR laser, due to the effective accumulation of RGD-QD-MoS2 NSs at the tumor sites through the RGD-integrin targeting and the enhanced penetration and retention (EPR) effect. Without showing any appreciable toxicity to treated cells or animals, RGD-QD-MoS2 NSs have been demostrated as promising multifunctional theranostic agents for cancer imaging and therapy.

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Publication details

The article was received on 19 Jul 2017, accepted on 09 Sep 2017 and first published on 11 Sep 2017


Article type: Paper
DOI: 10.1039/C7NR05278B
Citation: Nanoscale, 2017, Accepted Manuscript
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    RGD-QD-MoS2 nanosheets for targeted fluorescent imaging and photothermal therapy of cancer

    Y. Zhang, W. Xiu, Y. Sun, D. Zhu, Q. Zhang, L. Yuwen, L. Weng, Z. Teng and L. Wang, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05278B

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