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An Intelligent NIR-responsive Chelate Copper-based Anticancer Nanoplatform for Synergistic Tumor Targeted Chemo-phototherapy

Abstract

The chelate copper-based anticancer drug bleomycin (BLM) is admittedly believed to bind metal ions especially Cu (II) to generate the “Activated BLM” for DNA cleavage. Herein, BLM and L-menthol (LM) co-loaded hollow mesoporous Cu2-xS nanoparticles (HMCu2-xS NPs) with surface folic acid (FA) modification were formulated to construct an intelligent NIR-responsive nanoplatform for synergistic tumor targeted chemo-phototherapy. With the folate receptor (FR)-positive tumor targeting ability, the FA-HMCu2-xS/BLM/LM could pinpoint tumor cells efficiently. Under NIR irradiation, the versatile HMCu2-xS would be bound to exploit the merits of phototherapy (including PTT and PDT-like effect) for cancer treatment. Meanwhile, benefiting from the controllable “solid-liquid” (S-L) phase transition feature of LM as gatekeeper, FA-HMCu2-xS/BLM/LM offered a platform for NIR-mediated temperature-responsive BLM and copper ions release simultaneously, which further initiated the generation of the “Activated BLM”. As a matter of course, the remarkable synergistic combination of Cu-dependent chemo-phototherapy in vitro and in vivo by such smart all-in-one drug delivery nanoplatform developed here provided knowledge for advancing nanotherapy in biomedical fields.

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Publication details

The article was received on 11 Jul 2017, accepted on 09 Sep 2017 and first published on 11 Sep 2017


Article type: Paper
DOI: 10.1039/C7NR05003H
Citation: Nanoscale, 2017, Accepted Manuscript
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    An Intelligent NIR-responsive Chelate Copper-based Anticancer Nanoplatform for Synergistic Tumor Targeted Chemo-phototherapy

    Q. Feng, W. Zhang, Y. Li, X. Yang, Y. Hao, H. Zhang, W. Li, L. Hou and Z. Zhang, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR05003H

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