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Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy Triggered by Near-Infrared Light

Abstract

In the conventional non-invasive cancer treatments, such as photodynamic therapy (PDT) and photothermal therapy (PTT), light irradiation is focused precisely on cancer cells to induce apoptosis by generating reactive oxygen species (ROS) or localized heating. However, the over¬consumption of oxygen and the restricted diffusion distance of ROS limit the therapeutic effects on hypoxic tumors. We developed a platform for the rapid uptake of Au@Pt nanoparticles (NPs) labeled with a cell-targeting ligand (folic acid) and a mitochondria-targeting group (triphenylphosphine (TPP)) into mitochondria in cancer cells. Mitochondria were targeted via the subsequent loading of these Au@Pt NPs with a photosensitizer (Ce6), which led to significant improvement of PDT efficacy due to enhanced cellular uptake, an effective mitochondrial ROS burst and a rapid intelligent oxygen release. Meanwhile, Au@Pt NPs converse laser radiation into heat, resulting in thermally induced cell damage. This nanosystem could be adopted to be a dual-model phototherapeutic agent for enhanced cancer therapy and molecular targets associated with disease progression. We achieved a mitochondria-targeting multifunctional theranostic strategy (a combination of PDT and PTT) to improve theranostic efficiency substantially.

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Publication details

The article was received on 06 Jul 2017, accepted on 11 Sep 2017 and first published on 12 Sep 2017


Article type: Paper
DOI: 10.1039/C7NR04881E
Citation: Nanoscale, 2017, Accepted Manuscript
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    Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy Triggered by Near-Infrared Light

    Y. Song, Q. Shi, C. Zhu, Y. Luo, Q. Lu, H. Li, R. Ye, D. Du and Y. Lin, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR04881E

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