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Cis-platinum Pro-Drug-Attached CuFeS2 Nanoplates for In Vivo Photothermal/Photoacoustic Imaging and Chemotherapy /Photothermal Therapy of Cancer

Abstract

Photothermal therapy (PTT) has attracted considerable attention in cancer treatment. Herein, the facile synthesis of copper iron sulfide (chalcopyrite, CuFeS2) nanoplates (NPs) with well-defined shape were achieved by a template-mediated method. Chitosan (CS), a linear cationic polysaccharide, was used to improve the physiological stability and biocompatibility. CuFeS2 NPs with strong near-infrared (NIR) absorbance enables contrasts in photothermal and photoacoustic (PA) imaging. In vitro and in vivo tumor ablation studies further demonstrated that CS-functionalized CuFeS2 (CuFeS2-CS) NPs could convert 808 nm NIR light into heat for PTT with a photothermal conversion efficiency up to 30.5%, which was obviously higher than that of CuS NPs (only 21.4%). Furthermore, CuFeS2-CS NPs also could load cis-platinum pro-drug (CuFeS2-CS-Pt), and CuFeS2-CS-Pt showed a better synergistic therapeutic effect with respect to either chemotherapy or PTT alone.

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Publication details

The article was received on 12 Jun 2017, accepted on 11 Oct 2017 and first published on 12 Oct 2017


Article type: Paper
DOI: 10.1039/C7NR04166G
Citation: Nanoscale, 2017, Accepted Manuscript
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    Cis-platinum Pro-Drug-Attached CuFeS2 Nanoplates for In Vivo Photothermal/Photoacoustic Imaging and Chemotherapy /Photothermal Therapy of Cancer

    B. Ding, C. Yu, C. Li, X. Deng, J. Ding, Z. Cheng, B. Xing, P. Ma and J. Lin, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR04166G

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