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Highly oriented langmuir-blodgett film of silver cuboctahedra as an effective matrix-free sample plate in surface-assisted laser desorption/ionization mass spectrometry

Abstract

The design of a homogeneous sample plate to solve the sweet heating spot issues is the key step to expand the applicability in surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). Here, large-scale and highly oriented Langmuir-Blodgett (LB) films of uniform-shaped silver nanocrystals have been fabricated as a highly efficient and matrix-free sample plate in SALDI MS. Three individual silver nanocrystals such as cube, cuboctahedron and octahedron assembled LB films have been applied as the sample plates for glucose detections in SALDI MS without additional matrix. The results show that the signal intensity, background noise, signal-to-noise ratio and reproducibility have been significantly improved by using the LB films as the sample plate in comparison with commercial matrixes of CHCA and DHB. In particular, the relative signal of 5.7% has been obtained when the LB film of silver cuboctahedron has been applied. The great improvement in the SALDI MS measurement could be attributed to homogenous dissipation of the laser irradiation energy to create a large area of the sweet heating spot on well-oriented silver cuboctahedron LB film. This ready-to-use sample plate has revealed great commercial applications in SALDI MS.

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Publication details

The article was accepted on 30 Jun 2017 and first published on 07 Jul 2017


Article type: Paper
DOI: 10.1039/C7NR04098A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Highly oriented langmuir-blodgett film of silver cuboctahedra as an effective matrix-free sample plate in surface-assisted laser desorption/ionization mass spectrometry

    T. Kuo, Y. Chen, C. Wang, T. Shen, H. Wang, X. Pan, D. Wang, C. C. Liou, Y. Chang, Y. Chen, Y. Wu, Y. Liu, Y. Lin, C. Hu and C. Chen, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR04098A

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