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Label-free fluorescent immunoassay for Cu2+ ion detection based on UV degradation of immunocomplex and metal ion chelates

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Abstract

A mouse anti Cu2+-EDTA monoclonal antibody was used to capture EDTA chelated Cu2+ ions. Then UV radiation was utilized to degrade immunocomplex and Cu2+-EDTA chelates to release free Cu2+ ions. Based on their quenching effect to the fluorescent emission of CdSe/ZnS quantum dots, the released Cu2+ ions could be detected with ideal specificity and high sensitivity.

Graphical abstract: Label-free fluorescent immunoassay for Cu2+ ion detection based on UV degradation of immunocomplex and metal ion chelates

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Publication details

The article was received on 08 Jun 2017, accepted on 30 Jul 2017 and first published on 01 Aug 2017


Article type: Communication
DOI: 10.1039/C7NR04087C
Citation: Nanoscale, 2017, Advance Article
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    Label-free fluorescent immunoassay for Cu2+ ion detection based on UV degradation of immunocomplex and metal ion chelates

    Q. Shu, M. Liu, H. Ouyang and Z. Fu, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR04087C

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