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Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer

Abstract

TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980nm NIR triggered cancer synergistic platform. However, the pure traditional TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR to normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO2) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer. Properties of the nanocomposites, such as micro-morphology, size, drug loading ability and release, targeting performance, and therapy efficiency in vitro and in vivo were evaluated. The results indicated the core-shell nanocomposites with dramatically increased loading ability were pH-responsive/NIR-accelerated doxorubicin release nanocarriers, and showed synergistic breast cancer treatment in vitro and in vivo. This study verifies that the new prepared mSiO2 coated black TiO2 core-shell nanocarriers can overcome the limitations of traditional TiO2 nanocarriers, and therefore improve and broaden usage of TiO2 nanoparticles in nanomedicine.

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Publication details

The article was received on 07 Jun 2017, accepted on 14 Jul 2017 and first published on 14 Jul 2017


Article type: Paper
DOI: 10.1039/C7NR04039C
Citation: Nanoscale, 2017, Accepted Manuscript
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    Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer

    W. Ren, M. Z. Iqbal, L. Zeng, T. Chen, Y. Pan, J. Zhao, H. Yin, L. Zhang, J. Zhang, A. Li and A. Wu, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR04039C

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