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Coumarin-containing thermoresponsive hyaluronic acid-based nanogels as delivery systems for anticancer chemotherapy

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Abstract

Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light- and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues. Our findings indicate that coumarin-containing HA-based nanogels may be promising delivery systems for anticancer chemotherapy.

Graphical abstract: Coumarin-containing thermoresponsive hyaluronic acid-based nanogels as delivery systems for anticancer chemotherapy

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Publication details

The article was received on 04 Jun 2017, accepted on 22 Jul 2017 and first published on 25 Jul 2017


Article type: Paper
DOI: 10.1039/C7NR03964F
Citation: Nanoscale, 2017, Advance Article
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    Coumarin-containing thermoresponsive hyaluronic acid-based nanogels as delivery systems for anticancer chemotherapy

    T. F. Stefanello, B. Couturaud, A. Szarpak-Jankowska, D. Fournier, B. Louage, F. P. Garcia, C. V. Nakamura, B. G. De Geest, P. Woisel, B. van der Sanden and R. Auzély-Velty, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR03964F

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