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Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

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Abstract

We report the synthesis and characterization of antifouling zwitterion carboxybetaine acrylamide (CBAA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for enhanced CT imaging applications. The CBAA-modified nanodevice displays a better protein resistance property, less macrophage cellular uptake and liver accumulation, and longer blood half-delay time than the PEGylated counterpart material, thereby enabling enhanced blood pool, lymph node, and tumor CT imaging.

Graphical abstract: Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

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Publication details

The article was received on 03 Jun 2017, accepted on 31 Jul 2017 and first published on 01 Aug 2017


Article type: Communication
DOI: 10.1039/C7NR03940A
Citation: Nanoscale, 2017, Advance Article
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    Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

    Z. Xiong, Y. Wang, J. Zhu, X. Li, Y. He, J. Qu, M. Shen, J. Xia and X. Shi, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR03940A

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