Jump to main content
Jump to site search

Issue 33, 2017
Previous Article Next Article

A DNA bipedal nanowalker with a piston-like expulsion stroke

Author affiliations

Abstract

Artificial molecular walkers beyond burn-bridge designs are important for nanotechnology, but their systematic development remains difficult. Herein, we have reported a new rationally designed DNA walker–track system and experimentally verified a previously proposed general expulsion regime for implementing non-burn-bridge nanowalkers. The DNA walker has an optically powered engine motif that reversibly extends and contracts the walker via a quadruplex–duplex conformational change. The walker's extension is an energy-absorbing and force-generating process, which drives the walker's leg dissociation off-track in a piston-like expulsion stroke. The unzipping-shearing asymmetry provides the expulsion stroke a bias, which decides the direction of the walker. Moreover, three candidate walkers of different sizes were fabricated. Fluorescence motility experiments indicated two of them as successful walkers and revealed a distinctive size dependence that was expected for these expulsive walkers, but was not observed in previously reported walkers. This study identifies unique technical requirements for expulsive nanowalkers. The present DNA design is readily adapted for making similar walkers from other molecules since the unzipping-shearing asymmetry is common.

Graphical abstract: A DNA bipedal nanowalker with a piston-like expulsion stroke

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 May 2017, accepted on 31 Jul 2017 and first published on 02 Aug 2017


Article type: Paper
DOI: 10.1039/C7NR03809G
Citation: Nanoscale, 2017,9, 12142-12149
  • Open access: Creative Commons BY license
  •   Request permissions

    A DNA bipedal nanowalker with a piston-like expulsion stroke

    Q. Y. Yeo, I. Y. Loh, S. R. Tee, Y. H. Chiang, J. Cheng, M. H. Liu and Z. S. Wang, Nanoscale, 2017, 9, 12142
    DOI: 10.1039/C7NR03809G

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements