Jump to main content
Jump to site search


A Dual Modal Silver Bumpy Nanoprobe for Photoacoustic Imaging and SERS Multiplexed Identification of in vivo Lymph Node

Abstract

Multimodal imaging can provide complementary biomedical information which has huge potential in pre-clinical and clinical imaging and sensing. In this study, we introduce the dual modal NIR silver bumpy nanoprobes for in vivo imaging and multiplexed detection of biomolecules by both photoacoustic imaging (PAI) and surface-enhanced Raman scattering (SERS) techniques. For this study, we used silica-coated silver bumpy nanoshell probes (AgNS@SiO2). AgNS@SiO2 have strong NIR-absorption and scattering properties compared with other nanostructrues, and therefore, can be a good candidate for photoacoustic (PA) and SERS multimodal imaging. We obtained PA images of the skin and SLNs of rats by injecting various kinds of Raman-labeled AgNS@SiO2. Multiplexed identifications of the injected AgNS@SiO2 were achieved by measuring SERS signals. AgNS@SiO2 have the potential to be applied in detecting cancer biomarkers by locating biomarkers quickly using PA imaging, and identification by multiplexed target measurement using SERS signals in vivo.

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 May 2017, accepted on 27 Jul 2017 and first published on 28 Jul 2017


Article type: Paper
DOI: 10.1039/C7NR03742B
Citation: Nanoscale, 2017, Accepted Manuscript
  •   Request permissions

    A Dual Modal Silver Bumpy Nanoprobe for Photoacoustic Imaging and SERS Multiplexed Identification of in vivo Lymph Node

    M. G. Cha, S. Lee, S. Park, H. Kang, S. G. Lee, C. Jeong, Y. Lee, C. Kim and D. H. Jeong, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR03742B

Search articles by author

Spotlight

Advertisements