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Highly efficient dual-modal phosphorescence/ computed tomography bioprobes based on iridium complex and AuNPs polyiohexol composite nanoparticles

Abstract

On the basis of finite-difference time-domain simulations, a novel strategy is developed to prepare highly efficient bis(2-(2′-benzothienyl) pyridinato-N, C3′) iridium(BTP) and AuNPs polyiohexol composite nanoparticles (BAPI NPs) as dual-modal phosphorescence/computed tomography (CT) bioprobes. In these bioprobes, BTP and AuNPs are both encapsulated with polyiohexol NPs. All bioprobe components perform two functions here: AuNPs could be used as both CT contrast agent and phosphorescence enhancement reagent of BTP with metal-enhancement fluorescence effect. Results showed BAPI NPs were almost spherical in shape, with an average size of 50.36 ± 3.8 nm and higher total contrast agents loading ratio of 69.4%. Fourier transform infrared spectra confirmed that AuNPs and BTP are encapsulated in BAPI NPs. It is showed they have lower toxicity for tissues and cells, their phosphorescence intensity are 8.27-fold than that of BTP polyiohexol NPs (BPI NPs), the average phosphorescence intensity of the BAPI NPs were 1.46 times higher than that of BPI NPs and 5.85 times than that of BTP alone in vivo, improved CT imaging is obtained at low dose of polyiohexol in vivo, these bioprobes not only have highly efficient and excellent dual-modal imaginges, but also save the use of various materials , indicating this bioprobe is the potential dual-modal probes in future.

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Publication details

The article was received on 05 May 2017, accepted on 04 Jun 2017 and first published on 06 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR03185H
Citation: Nanoscale, 2017, Accepted Manuscript
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    Highly efficient dual-modal phosphorescence/ computed tomography bioprobes based on iridium complex and AuNPs polyiohexol composite nanoparticles

    Y. Yu, Y. Wu, J. Liu, Y. Liu and D. Wu, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR03185H

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