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G2-S16 dendrimer as a candidate for microbicide to prevent from HIV-1 infection in women

Abstract

Unprotected heterosexual intercourse is the first route sustaining the global spread of HIV-1, being responsible for 80% of new HIV-1 infection in the world.The presence of inflammation in the female reproductive tract (FRT)and in semen increases the risk of heterosexual HIV-1 transmission. Our state-of-the-art research based on innovative nanotechnology design was focused on toxicological study such as the limitation of the activity of the novel water-soluble anionic carbosilanedendrimerG2-S16 in the adult cervical and foreskin epithelia.Our G2-S16 dendrimerdid not cause any irritation and inflammationin the vaginal epithelium,proving that this dendrimeris a safe nanocompound for vaginal application to control viral transmission. It was shown that no significant differences were found in mortality, sublethal or teratogenic effects when the zebrafishembryos were treated with G2-S16. In nutshell, G2-S16 stands up as an ideal candidate for the development of a topical microbicide against HIV-1 infection and it is ready to step into the clinical trials due to its great in vivo biocompatibility, as well as due to its ability to halt HIV-1 infection in presence of semen.

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Publication details

The article was received on 28 Apr 2017, accepted on 13 Jun 2017 and first published on 16 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR03034G
Citation: Nanoscale, 2017, Accepted Manuscript
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    G2-S16 dendrimer as a candidate for microbicide to prevent from HIV-1 infection in women

    R. Ceña-Diez, P. García-Broncano, J. de la Mata, R. Gomez Ramirez, S. Resino and M. Á. Muñoz-Fernández, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR03034G

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