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Issue 30, 2017
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A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

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Abstract

A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

Graphical abstract: A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

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Publication details

The article was received on 25 Apr 2017, accepted on 26 Jun 2017 and first published on 28 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02949G
Citation: Nanoscale, 2017,9, 10854-10860
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    A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

    Y. Kim, L. Wang, R. Landis, C. S. Kim, R. W. Vachet and V. M. Rotello, Nanoscale, 2017, 9, 10854
    DOI: 10.1039/C7NR02949G

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