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Layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Abstract

A chip-based platform for laser desorption/ionization mass spectromatry (LDI-MS) analysis of small molecules was developed by utlizing layer-by-layer (LBL) assemmbly of MoS2 nanoflake and polyallyamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 film exhibit high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distributions, and its performance was further enhaced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

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Publication details

The article was received on 25 Apr 2017, accepted on 26 Jun 2017 and first published on 28 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02949G
Citation: Nanoscale, 2017, Accepted Manuscript
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    Layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

    Y. Kim, L. Wang, R. Landis, C. S. Kim, R. Vachet and V. Rotello, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02949G

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