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Issue 39, 2017
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Hierarchical thermoplastic rippled nanostructures regulate Schwann cell adhesion, morphology and spatial organization

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Abstract

Periodic ripples are a variety of anisotropic nanostructures that can be realized by ion beam irradiation on a wide range of solid surfaces. Only a few authors have investigated these surfaces for tuning the response of biological systems, probably because it is challenging to directly produce them in materials that well sustain long-term cellular cultures. Here, hierarchical rippled nanotopographies with a lateral periodicity of ∼300 nm are produced from a gold-irradiated germanium mold in polyethylene terephthalate (PET), a biocompatible polymer approved by the US Food and Drug Administration for clinical applications, by a novel three-step embossing process. The effects of nano-ripples on Schwann Cells (SCs) are studied in view of their possible use for nerve-repair applications. The data demonstrate that nano-ripples can enhance short-term SC adhesion and proliferation (3–24 h after seeding), drive their actin cytoskeleton spatial organization and sustain long-term cell growth. Notably, SCs are oriented perpendicularly with respect to the nanopattern lines. These results provide information about the possible use of hierarchical nano-rippled elements for nerve-regeneration protocols.

Graphical abstract: Hierarchical thermoplastic rippled nanostructures regulate Schwann cell adhesion, morphology and spatial organization

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Publication details

The article was received on 20 Apr 2017, accepted on 01 Sep 2017 and first published on 06 Sep 2017


Article type: Paper
DOI: 10.1039/C7NR02822A
Citation: Nanoscale, 2017,9, 14861-14874
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    Hierarchical thermoplastic rippled nanostructures regulate Schwann cell adhesion, morphology and spatial organization

    C. Masciullo, R. Dell'Anna, I. Tonazzini, R. Böettger, G. Pepponi and M. Cecchini, Nanoscale, 2017, 9, 14861
    DOI: 10.1039/C7NR02822A

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