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Issue 28, 2017
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Tile-based self-assembly of a triple-helical polysaccharide into cell wall-like mesoporous nanocapsules

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Abstract

Tile-based self-assembly is a robust system in the construction of three-dimensional DNA nanostructures but it has been rarely applied to other helical biopolymers. β-Glucan is an immunoactive natural polymer which exists in a triple helical conformation. Herein, we report that β-glucan, after modification using two types of short chain acyl groups, can self-assemble into tiles with inactivated sticky ends at the interface of two solvents. These tiles consist of a single layer of helices laterally aligned, and the sticky ends can be activated when a few acyl groups at the ends are removed; these tiles can further pack into mesoporous nanocapsules, in a similar process as the sticky DNA tiles pack into complex polyhedral nano-objects. These nanocapsules were found to have targeted effects to antigen presenting cells in a RAW264.7 cell model. Our study suggests that tile-based self-assembly can be a general strategy for helical biopolymers, and on fully exploiting this strategy, various new functional nanostructures will become accessible in the future.

Graphical abstract: Tile-based self-assembly of a triple-helical polysaccharide into cell wall-like mesoporous nanocapsules

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Publication details

The article was received on 27 Apr 2017, accepted on 22 Jun 2017 and first published on 23 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02801F
Citation: Nanoscale, 2017,9, 9938-9945
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    Tile-based self-assembly of a triple-helical polysaccharide into cell wall-like mesoporous nanocapsules

    C. Wu, X. Wang, J. Wang, Z. Zhang, Z. Wang, Y. Wang and S. Tang, Nanoscale, 2017, 9, 9938
    DOI: 10.1039/C7NR02801F

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