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Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature

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Abstract

Angiogenesis is a dynamic process fundamental to the development of solid tumors. Epidermal growth factor-like domain 7 (EGFL7) is a protein whose expression is restricted to endothelial cells undergoing active remodeling that has emerged as a key mediator of this process. EGFL7 expression is associated with poor outcome in several cancers, making it a promising target for imaging or therapeutic strategies. Here, EGFL7 is explored as a molecular target for active neovascularization. Using a combinatorial peptide screening approach, we describe the discovery and characterization of a novel high affinity EGFL7-binding peptide, E7p72, that specifically targets human endothelial cells. Viral nanoparticles decorated with E7p72 peptides specifically target tumor-associated neovasculature with high specificity as assessed by intravital imaging. This work highlights the value of EGFL7 as a target for angiogenic vessels and opens the door for novel targeted therapeutic approaches.

Graphical abstract: Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature

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Publication details

The article was received on 10 Apr 2017, accepted on 31 Jul 2017 and first published on 01 Aug 2017


Article type: Paper
DOI: 10.1039/C7NR02558K
Citation: Nanoscale, 2017, Advance Article
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    Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature

    C. Cho, L. Yu, T. K. Nsiama, A. N. Kadam, A. Raturi, S. Shukla, G. A. Amadei, N. F. Steinmetz, L. G. Luyt and J. D. Lewis, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR02558K

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