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Issue 32, 2017
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Fluorine substitution enhances the self-assembling ability of hydrogelators

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Abstract

When supramolecular hydrogels are applied as tissue culture scaffolds, their mechanical strength and biocompatibility are the two most important factors that must be considered. However, systematic studies on the structure–mechanical property (or structure–cytotoxicity) relationship of hydrogels are rare. Herein, we rationally designed three hydrogelators and their corresponding phosphate precursors, and systematically studied their self-assembling ability and cytotoxicity. The results indicated that fluorine substitution, but not trifluoromethyl substitution with more fluorine atoms, to the phenylalanine motif enhanced the self-assembling ability and cytotoxicity of the hydrogelators (or precursors). We envision that our preliminary study of hydrogelator fluorination would provide a strategy for the development of supramolecular hydrogels for wider biomedical applications.

Graphical abstract: Fluorine substitution enhances the self-assembling ability of hydrogelators

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Publication details

The article was received on 08 Apr 2017, accepted on 16 Jul 2017 and first published on 19 Jul 2017


Article type: Communication
DOI: 10.1039/C7NR02499A
Citation: Nanoscale, 2017,9, 11429-11433
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    Fluorine substitution enhances the self-assembling ability of hydrogelators

    C. Wu, Z. Zheng, Y. Guo, C. Tian, Q. Xue and G. Liang, Nanoscale, 2017, 9, 11429
    DOI: 10.1039/C7NR02499A

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