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Five-Nanometer ZnSn2O4: Cr, Eu Ultra-Small Nanoparticles as New Near Infrared-Emitting Persistent Luminescent Nanoprobes for Cellular and Deep Tissue Imaging at 800 nm

Abstract

Until now, the afterglow emissions of most developed near infrared (NIR)-emitting persistent luminescent nanoparticles (NPLNPs) were located at approximately 700 nm, belonging to the edge of the first tissue transparency window (from 650 to 900 nm), which resulted in the relatively low tissue penetration and signal-to-noise ratio (SNR) for in vivo imaging. Herein, 5-nm ZnSn2O4: Cr, Eu (ZSO) NPLNPs with NIR afterglow emission at 800 nm was synthesized via a direct aqueous-phase synthesis method. The longer NIR afterglow emission of ZSO NPLNPs can easily penetrate approximately 3 cm of pork tissue. Furthermore, even though the backbones blocked part of the NIR afterglow light, the high SNR (25.5) in vivo images can be observed from the mouse back and can be maintained for more than 15 min. The ZSO nanoprobes conjugated with folic acid exhibited excellent in vitro and in vivo tumor targeting capacity, which was advantageous for accurate tumor diagnosis. More importantly, the ZSO NPLNPs can be re-excited in situ and in vivo using NIR light to realize renewable near-infrared persistent luminescence in vivo, which was helpful for super long time and higher SNR in vitro and in vivo imaging.

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Publication details

The article was received on 07 Apr 2017, accepted on 18 May 2017 and first published on 19 May 2017


Article type: Paper
DOI: 10.1039/C7NR02468A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Five-Nanometer ZnSn2O4: Cr, Eu Ultra-Small Nanoparticles as New Near Infrared-Emitting Persistent Luminescent Nanoprobes for Cellular and Deep Tissue Imaging at 800 nm

    J. Li, J. Shi, C. Wang, P. Li, Y. Zhen-feng and H. Zhang, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02468A

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