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Au–Cu core–shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles

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Abstract

Au–Cu core–shell nanocubes and octahedra synthesized in aqueous solution were employed to catalyze a 1,3-dipolar cycloaddition reaction between phenylacetylene and benzyl azide in water at 50 °C for 3 h. Interestingly, the nanocubes were far more efficient in catalyzing this reaction, giving 91% yield of a regioselective 1,4-triazole product, while octahedra only recorded 46% yield. The Au–Cu nanocubes were subsequently employed to catalyze the click reaction between benzyl azide and a broad range of aromatic and aliphatic alkynes. The product yields ranged from 78 to 99%. Clearly the Au–Cu cubes exposing {100} surfaces are an excellent and green catalyst for click reactions.

Graphical abstract: Au–Cu core–shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles

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Publication details

The article was received on 07 Apr 2017, accepted on 27 Apr 2017 and first published on 02 May 2017


Article type: Communication
DOI: 10.1039/C7NR02466E
Citation: Nanoscale, 2017, Advance Article
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    Au–Cu core–shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles

    M. Madasu, C. Hsia and M. H. Huang, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR02466E

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