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Selective Cleavage of Polyphosphoester in Crosslinked Copper based Nanogels: Enhanced Antibacterial Performance Through Controlled release of Copper

Abstract

Polymeric architectures with controlled and well-defined structural feature is required to render sustainable antibacterial surface; a key requirement in the design of polymeric membranes for water purification. Herein, surface selective crosslinking of copper oxide–polyphosphoester (CuO-PPE) hybrid nanogels on to polyvinylidene fluoride–styrene maleic anhydride (PVDF/SMA) ultrafiltration membranes was developed. The hybrid nanogels, composed of PPE and CuO, with inherent antifouling and antibacterial properties, were crosslinked using a macroinitiator (polyethylene glycol, PEG) and subsequently grafted on to PVDF/SMA by alkyne-addition reaction. Hydrolysed SMA solubilizes membrane proteins and the phosphatase/phospholipase triggers the cleavage of PPE segments resulting in controlled release of Cu ions. This unique strategy renders the membrane surface antibacterial through sustained and controlled release of Cu ions thereby generating intracellular reactive oxygen species (ROS). In addition, the enhanced antibiofouling performance of these membranes is facilitated by the presence of the hydrophilic macroinitiator (PEG). The modified membranes designed in this study are durable and possess long-term stability due to strong covalent interaction between CuO-PPE and with PVDF/SMA membrane. Flux, porosity and protein adsorption studies on the membranes were performed. An enhanced flux and recovery ratio were observed for the modified membrane due to the pendant PPE groups (from CuO-PPE) which prohibits irreversible protein adsorption on the PVDF surface. The cytotoxicity of CuO-PPE is greatly reduced because of an effective coverage of CuO by biocompatible PPEs. This study opens up new avenues of fabricating “smart” inorganic nanoparticles that can be confined into soft hybrid polymeric gel network with controlled release of Cu ions thereby precluding from ubiquitous bacterial treatment in water filtration system.

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Publication details

The article was received on 06 Apr 2017, accepted on 28 Jul 2017 and first published on 28 Jul 2017


Article type: Paper
DOI: 10.1039/C7NR02446K
Citation: Nanoscale, 2017, Accepted Manuscript
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    Selective Cleavage of Polyphosphoester in Crosslinked Copper based Nanogels: Enhanced Antibacterial Performance Through Controlled release of Copper

    P. nagarajan, P. K. K. Samantaray, L. Das, G. Madras and S. Bose, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02446K

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