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Damage-Free Tip-Enhanced Raman Spectroscopy for Heat-Sensitive Materials

Abstract

We report a method to establish experimental conditions for tip-enhanced Raman spectroscopy (TERS) with low thermal and mechanical damage to samples. In this method, we monitor thermal desorption of thiol molecules from a gold-coated probe of an atomic force microscope (AFM) via TERS spectra. Temperatures for desorption of thiol molecules (60-100˚C) from gold surfaces covers the temperature range for degradation of heat-sensitive biomaterials (e.g. proteins). By monitoring desorption of thiols on the probe, we can estimate the power of excitation laser for the samples to reach their critical temperatures for thermal degradation. Furthermore, we also found that an active oscillation of AFM cantilevers significantly promotes the heat transfer from the probe to the surrounding medium. This enables us to employ higher power density of the excitation laser, resulting in a stronger Raman signal compared with the signal obtained with a contact mode. We propose that this combinatory method is effective in acquiring strong TERS signals while suppressing thermal and mechanical damages on soft and heat-sensitive samples.

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Publication details

The article was received on 04 Apr 2017, accepted on 08 Jun 2017 and first published on 12 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02398G
Citation: Nanoscale, 2017, Accepted Manuscript
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    Damage-Free Tip-Enhanced Raman Spectroscopy for Heat-Sensitive Materials

    M. Mochiduki, G. Lkhamsuren, K. Suthiwanich, E. Angelo Mondarte, T. Yano, M. Hara and T. Hayashi, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02398G

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