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A cation-exchange controlled core–shell MnS@Bi2S3 theranostic platform for multimodal imaging guided radiation therapy with hyperthermia boost

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Abstract

Overtreatment as a crucial modern medicine issue needs to be urgently addressed. Theranostic agents supply a unique platform and integrate multiple diagnosis and therapies to deal with this issue. In this study, a core–shell MnS@Bi2S3 nanostructure was fabricated via two step reactions for tri-modal imaging guided thermo-radio synergistic therapy. The mass ratio between the core and shell of the constructed MnS@Bi2S3 can be precisely controlled via cation exchange reaction. After surface PEGylation, MnS@Bi2S3-PEG nanoparticles exhibited excellent aqueous medium dispersibility for bioapplications. Based on the r1 and r2 relaxivity obtained from the MnS core and the strong near-infrared absorption and X-ray attenuation abilities of the Bi2S3 shell, the intratumoral injected MnS@Bi2S3-PEG can realize in vivo magnetic resonance, computer tomography, and photoacoustic tumor imaging under a single injection dose. Hyperthermia significantly boosts the efficacy of radiation therapy, showing synergistic tumor treatment efficacy. No obvious toxicity is monitored for the treated mice. Our study not only provides a new way to precisely construct the core–shell nanocomposite, but also presents a unique theranostic platform and unifies the solutions for the challenges related with high injection dose and overtreatment.

Graphical abstract: A cation-exchange controlled core–shell MnS@Bi2S3 theranostic platform for multimodal imaging guided radiation therapy with hyperthermia boost

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Publication details

The article was received on 04 Apr 2017, accepted on 25 Jun 2017 and first published on 26 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02384G
Citation: Nanoscale, 2017, Advance Article
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    A cation-exchange controlled core–shell MnS@Bi2S3 theranostic platform for multimodal imaging guided radiation therapy with hyperthermia boost

    Y. Li, Y. Sun, T. Cao, Q. Su, Z. Li, M. Huang, R. Ouyang, H. Chang, S. Zhang and Y. Miao, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR02384G

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