Jump to main content
Jump to site search


In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy

Author affiliations

Abstract

A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility. The final UCNPs@Au-DOX nanocomposites offer efficient treatment effects in vitro under irradiation with an 808 nm laser due to the synergistic effect of chemotherapy and photothermal therapy. In addition, the UCNPs@Au-DOX nanocomposites show excellent intracellular locating ability via upconversion luminescence (UCL) imaging with Er3+ ions and magnetic resonance imaging (MRI) with Gd3+ ions, indicating that they have potential as a visual tracking agent in cancer treatment. Therefore, the presented bioimaging-guided multifunctional synergistic therapy nanocomposites are promising tools for imaging-guided cancer therapy.

Graphical abstract: In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Mar 2017, accepted on 13 Jun 2017 and first published on 14 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02280H
Citation: Nanoscale, 2017, Advance Article
  •   Request permissions

    In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy

    R. Wei, W. Xi, H. Wang, J. Liu, T. Mayr, L. Shi and L. Sun, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR02280H

Search articles by author

Spotlight

Advertisements