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Bio-camouflage of Anatase Nanoparticles Explored by In Situ High-Resolution Electron Microscopy

Abstract

While titanium is the metal of choice for most prothetics and inner body devices due to its superior biocompatability, the discovery of Ti-containing species in the adjacent tissue as the result of wear and corrosion has been associated with autoimmune diseases and premature implant failures. Here, we utilize the in-situ liquid cell transmission electron microscopy (TEM) in a liquid flow holder and graphene liquid cells (GLCs) were used to investigate, for the first time, the in situ nano-bio interactions between titanium dioxide nanoparticles and biological medium. This imaging and spectroscopy methodology showed the process of formation of a ionic and proteic bio-camouflage surrounding Ti dioxide (anatase) nanoparticles that facilitates their internalization by bone cells. The in situ understanding of the mechanisms of formation of the bio-camouflage of anatase nanoparticles may contribute for the definition of strategies aimed to the manipulation of these NPs for bone regenerative purposes.

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Publication details

The article was received on 29 Mar 2017, accepted on 31 May 2017 and first published on 01 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02239E
Citation: Nanoscale, 2017, Accepted Manuscript
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    Bio-camouflage of Anatase Nanoparticles Explored by In Situ High-Resolution Electron Microscopy

    A. Ribeiro, A. Mukherjee, X. Hu, S. Shafien, R. Ghodsi, K. He, S. G. Piper, C. Wang, R. F. Klie, T. Shokuhfar, R. Shahbazian-Yassar, R. Borojevic, L. A. Rocha and J. M. Granjeiro, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02239E

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