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Issue 30, 2017
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Bio-camouflage of anatase nanoparticles explored by in situ high-resolution electron microscopy

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Abstract

While titanium is the metal of choice for most prosthetics and inner body devices due to its superior biocompatibility, the discovery of Ti-containing species in the adjacent tissue as a result of wear and corrosion has been associated with autoimmune diseases and premature implant failures. Here, we utilize the in situ liquid cell transmission electron microscopy (TEM) in a liquid flow holder and graphene liquid cells (GLCs) to investigate, for the first time, the in situ nano–bio interactions between titanium dioxide nanoparticles and biological medium. This imaging and spectroscopy methodology showed the process of formation of an ionic and proteic bio-camouflage surrounding Ti dioxide (anatase) nanoparticles that facilitates their internalization by bone cells. The in situ understanding of the mechanisms of the formation of the bio-camouflage of anatase nanoparticles may contribute to the definition of strategies aimed at the manipulation of these NPs for bone regenerative purposes.

Graphical abstract: Bio-camouflage of anatase nanoparticles explored by in situ high-resolution electron microscopy

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Publication details

The article was received on 29 Mar 2017, accepted on 31 May 2017 and first published on 01 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02239E
Citation: Nanoscale, 2017,9, 10684-10693
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    Bio-camouflage of anatase nanoparticles explored by in situ high-resolution electron microscopy

    A. R. Ribeiro, A. Mukherjee, X. Hu, S. Shafien, R. Ghodsi, K. He, S. Gemini-Piperni, C. Wang, R. F. Klie, T. Shokuhfar, R. Shahbazian-Yassar, R. Borojevic, L. A. Rocha and J. M. Granjeiro, Nanoscale, 2017, 9, 10684
    DOI: 10.1039/C7NR02239E

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