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DNA Origami/Gold Nanorods Hybrid Nanostructures for the Circumvention of Drug Resistance

Abstract

We herein demonstrate that DNA origami can work as a multifunctional platform integrating chemotherapeutic drug (doxorubicin), gold nanorods and tumour-specific aptamer MUC-1, to realize the effective circumvention of drug resistance. Doxorubicin (DOX) was loaded efficiently onto DNA origami through base pairs intercalation and surface-modified gold nanorods (AuNRs) were assembled onto DNA origami through DNA hybridization. Due to the active targeting effect of assembled aptamers, the multifunctional nanostructures achieved increased cellular internalization of DOX and AuNRs. Upon near-infrared (NIR) laser irradiation, P-glycoprotein (multidrug resistance pump) expression of multidrug resistant MCF-7 (MCF-7/ADR) cells was down-regulated, achieving the synergistically chemotherapeutic (DOX) and photothermal (AuNRs) effects.

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Publication details

The article was received on 29 Mar 2017, accepted on 12 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7NR02222K
Citation: Nanoscale, 2017, Accepted Manuscript
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    DNA Origami/Gold Nanorods Hybrid Nanostructures for the Circumvention of Drug Resistance

    L. Song, Q. Jiang, J. Liu, N. Li, Q. Liu, L. Dai, Y. Gao, W. Liu, D. Liu and B. Ding, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02222K

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