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Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement

Abstract

Integrating radiation therapy with high-depth photothermal therapy in the second near-infrared (NIR) window is highly required for efficient treatment of the deep-seated tumor cells. Here, we constructed a multifunctional nano-theranostics with bimetallic chalcogenide nanocrystals (NCs) functionalized with amphiphilic D-α-tocopherol polyethylene glycol 1000 succinate (TPGS-Cu3BiS3). Benefiting from the strong absorbance of both X-ray and NIR light in the second NIR window, TPGS-Cu3BiS3 CNs can not only deposit more radiation dose to trigger enhanced radiation damage in vivo, but also conduct photo-induced hyperthermia for thermal ablation in the second NIR window and effective improvement of tumor oxygenation to overcome the hypoxia-associated radio-resistance of tumors. Moreover, copper ions on the surface of TPGS-Cu3BiS3 NCs are capable of catalyzing the Fenton-like and Haber-Weiss reactions to produce highly reactive hydroxyl radical, leading to increase the level of oxygen radicals and further enhance cancer cell destruction. Apart from their therapeutic application, by means of X-ray computer tomography imaging as well as multispectral optoacoustic tomography imaging, TPGS-Cu3BiS3 NCs also have the potential as a nano-theranostics to offer the remarkable therapeutic outcome for the deep-seated tumor cells in the imaging-guided synergistically enhanced radiation therapy.

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Publication details

The article was received on 29 Mar 2017, accepted on 10 May 2017 and first published on 12 May 2017


Article type: Paper
DOI: 10.1039/C7NR02213A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement

    L. YAN, J. Du, X. Zheng, Y. Yong, J. Yu, X. Dong, C. Zhang, R. Zhou, B. Li, C. Chen, Z. Gu and Y. Zhao, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02213A

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