Jump to main content
Jump to site search


One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis

Author affiliations

Abstract

Carbon dots (CDs) with high quantum yield (QY), low toxicity and good biocompatibility are the major quests of biomedical research. In this paper, we develop a green, simple hydrothermal approach to synthesize water-soluble, nontoxic, highly photoluminescent carbon nanodots (CNDs) from Metronidazole, which possess selective antibacterial activity against obligate anaerobes for the first time. Metronidazole was used as a sole precursor to prepare CNDs at 250 °C (CNDs-250) for 8 h. After the CNDs-250 with an average size of 2.9 nm, consisting of a highly carbon crystalline core and various surface groups were obtained, the formation and fluorescence mechanisms of CNDs were further explored by adjusting the reaction time and reaction temperatures, respectively. Biological experimental data proved that CNDs-250 can only inhibit the growth of obligate anaerobes, such as Porphyromonas gingivalis (P. gingivalis) directly, instead of further functionalization. Besides, CNDs-250 with a QY around 28.1% exhibit an obvious excitation-dependent emission, which will be conducive to multicolor bioimaging. And it may not only develop a new approach for researchers to prepare multifunctional CDs, but also provide a valuable strategy for the theranostics of some diseases as well as other fields.

Graphical abstract: One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 25 Mar 2017, accepted on 18 Apr 2017 and first published on 20 Apr 2017


Article type: Paper
DOI: 10.1039/C7NR02128C
Citation: Nanoscale, 2017, Advance Article
  •   Request permissions

    One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis

    J. Liu, S. Lu, Q. Tang, K. Zhang, W. Yu, H. Sun and B. Yang, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR02128C

Search articles by author