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Quantitative and correlative biodistribution analysis of 89Zr-labeled mesoporous silica nanoparticles intravenously injected into tumor-bearing mice

Abstract

The biodistribution of 89Zr-labeled mesoporous silica nanoparticles (MSNs) was evaluated in details using a prostate cancer mouse model bearing LNCaP C4-2 and PC-3 tumor xenografts with focus on passive targeting. PEGylation of radiolabeled MSNs significantly improved the blood circulation times and radically enhanced the accumulation in tumors comparable to accumulation levels previously reported for similar but actively targeted particles. The distribution of the passively targeted MSNs was related to the degree of vascularization of the tumors and did not follow the trends observed in vitro. Correlative analyses of organ-to-blood ratios revealed that little or no accumulation of the particles is observed in lungs, heart, and brain, and that the particles detected were present in the blood pool. On the other hand, clear accumulation was observed in liver and spleen, in addition to the uptake in the tumors. The accumulation of particles in the kidney did not correlate with the MSN concentration in the blood, but indicated a rather steady level of particles in the kidney. The results, which partly contradict previous studies, highlight the importance of correlative analyses in order to evaluate organ accumulation of particles.

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Publication details

The article was received on 22 Mar 2017, accepted on 01 Jun 2017 and first published on 07 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR02050C
Citation: Nanoscale, 2017, Accepted Manuscript
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    Quantitative and correlative biodistribution analysis of 89Zr-labeled mesoporous silica nanoparticles intravenously injected into tumor-bearing mice

    L. Kramer, G. Winter, B. Baur, A. Kuntz, T. Kull, C. Solbach, A. Beer and M. Linden, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR02050C

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