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Bifunctional Plasmonic-Magnetic Particles for an Enhanced Microfluidic SERS Immunoassay

Abstract

Surface-Enhanced Raman Scattering (SERS) is emerging as a promising strategy for quantification of immunoglobulin G (IgG) due to its inherent high sensitivity and specificity, however, it remains challenging to integrate SERS detection with microfluidic system in a simple, efficient and low-cost manner. Here, we report on a novel bifunctional plasmonic-magnetic particles-based immunoassay, in which plasmonic nanoparticles act as soluble SERS immunosubstrates, whereas magnetic particles are for promoting micromixing in a microfluidic chip. With this novel SERS immunosubstrate in conjunction with the unique microfluidic system, we could substantially reduce the assay time from 4 hours to 80 minutes as well as enhance detection specificity by about 70% in comparison to non-microfluidic immunoassay. Compared to previous microfluidic SERS system, our strategy offers a simple microfluidic chip design with only one well for mixing, washing and detection.

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Publication details

The article was received on 01 Mar 2017, accepted on 28 Apr 2017 and first published on 03 May 2017


Article type: Paper
DOI: 10.1039/C7NR01511A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Bifunctional Plasmonic-Magnetic Particles for an Enhanced Microfluidic SERS Immunoassay

    L. W. Yap, H. Chen, Y. Gao, K. Petkovic, Y. Liang, K. J. Si, H. Wang, Z. Tang, Y. Zhu and W. Cheng, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR01511A

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