Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

Author affiliations

Abstract

Single or few-layered MoS2 nanosheets, as a novel class of 2D nanomaterials, have received tremendous attention due to their fantastic physical and chemical properties. Here, we fabricated MoS2–PEG–CpG with a small and uniform size as a multifunctional platform for photothermal enhanced immunotherapy. MoS2 nanosheets were fabricated by chemical exfoliation and further probe sonication. To realize MoS2-based adjuvant delivery, MoS2 nanosheets were functionalized with cytosine–phosphate–guanine (CpG) and polyethylene glycol (PEG) to form MoS2–PEG–CpG nanoconjugates. As an efficient nanocarrier with excellent near infrared-light (NIR) absorbing performance, MoS2–PEG–CpG significantly promotes CpG intracellular accumulation and the effect can be further enhanced by photothermal treatment. In addition, the enhanced uptake can stimulate the production of proinflammatory cytokines and remarkably elevate the immune response level. Finally, we found that MoS2–PEG–CpG could reduce the proliferative activity of cancer cells when co-cultured with a macrophage-like cell upon NIR irradiation, implying a novel strategy for multifunctional therapeutics against cancers.

Graphical abstract: CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 28 Feb 2017, accepted on 12 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7NR01460K
Citation: Nanoscale, 2017, Advance Article
  •   Request permissions

    CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

    Q. Han, X. Wang, X. Jia, S. Cai, W. Liang, Y. Qin, R. Yang and C. Wang, Nanoscale, 2017, Advance Article , DOI: 10.1039/C7NR01460K

Search articles by author