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Issue 20, 2017
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Rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared persistent luminescence nanoprobes for background-free biodetection

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Abstract

Persistent luminescence nanoparticles (PLNPs) have shown great promise in the field of biomedicine, but are currently limited by the challenge in the synthesis of high-quality PLNPs with bright persistent luminescence and a long afterglow time. Herein, we report a facile strategy for the synthesis of monodisperse, rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared (NIR) PLNPs based on a modified solvothermal liquid–solid-solution method. The as-synthesized PLNPs are not only flexible for bioconjugation, but could also circumvent the limitation of the weak persistent luminescence and short afterglow time that most PLNPs confronted owing to their rechargeable capability. It was unraveled that both thermal activation and quantum tunneling mechanisms contributed to the afterglow decay of the PLNPs, and the quantum tunneling was found to dictate the LED-activated afterglow intensity and lasting time. Furthermore, by utilizing the superior excitation-free persistent luminescence, we demonstrated for the first time the application of biotinylated ZnGa2O4 : Cr3+ PLNPs as background-free luminescent nano-bioprobes for sensitive and specific detection of avidin in a heterogeneous assay with a limit of detection down to ∼150 pM, thus revealing the great potential of these NIR PLNPs in ultrasensitive biodetection and bioimaging.

Graphical abstract: Rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared persistent luminescence nanoprobes for background-free biodetection

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Publication details

The article was received on 17 Feb 2017, accepted on 20 Apr 2017 and first published on 21 Apr 2017


Article type: Paper
DOI: 10.1039/C7NR01209H
Citation: Nanoscale, 2017,9, 6846-6853
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    Rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared persistent luminescence nanoprobes for background-free biodetection

    Z. Zhou, W. Zheng, J. Kong, Y. Liu, P. Huang, S. Zhou, Z. Chen, J. Shi and X. Chen, Nanoscale, 2017, 9, 6846
    DOI: 10.1039/C7NR01209H

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