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Issue 21, 2017
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Highly water-stable rare ternary Ag–Au–Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents

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Abstract

X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag–Au–Se chalcogenide nanoparticles (NP). A facile ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic acid as an anchor group resulted in highly water-soluble and monodisperse nanoparticles. These PEGylated ternary NPs were tested in vivo in mice, showing slow uptake by the mononuclear phagocyte system, long blood circulation times, low toxicity, and very good X-ray contrast, thus being promising candidates as CT contrast agents for clinical applications.

Graphical abstract: Highly water-stable rare ternary Ag–Au–Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents

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Publication details

The article was received on 14 Feb 2017, accepted on 22 Apr 2017 and first published on 25 Apr 2017


Article type: Paper
DOI: 10.1039/C7NR01110E
Citation: Nanoscale, 2017,9, 7242-7251
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    Highly water-stable rare ternary Ag–Au–Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents

    C. Caro, M. Dalmases, A. Figuerola, M. L. García-Martín and M. P. Leal, Nanoscale, 2017, 9, 7242
    DOI: 10.1039/C7NR01110E

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